The GMT800-based Suburbans were introduced in late 1999 as the 2000 model year. Chevrolet sold two models of Suburbans: 1/2 ton and 3/4 ton. They came in either LS or LT trim packages. All models came in either 2wd or optional push button 4wd(w/ low range transfer case). A tow hitch with a trailer brake controller was standard.

2001: Both the LT now came with OnStar standard. The 6.0 liter (364 cu in) put out 20 horsepower (15 kW) more, and an 8.1 liter (496 cu in) was an option for the 3/4 ton.

2002: Many features from the options list were added to the standard equipment on the LS model, including A/C, Alloy wheels, Power Windows, Power Front seats, and Rear HVAC Controls. A Z71 off-road package was added for 2002, which included special body moldings and special 17-inch (430 mm) wheels with aggressive tread tires, the package was only available with four wheel drive.

2003: Responding to many critics of GM's hard plastic and cold, unfriendly looking interiors, the Suburban and the rest of Chevrolet's line of full size trucks received reworked interiors, complete with RDS radio, tri-zone climate control(driver, passenger, and rear seats), new power window switches, a more ergonomic steering wheel with audio controls, Power adjustable pedals, Stability Control, and many other entertainment options and creature comforts.