The Nissan Murano is a mid-size crossover SUV first manufactured by Nissan in December 2002 and sold as a 2003 model. Nissan introduced the Murano as its first crossover SUV for the United States and Canada. Designed at Nissan Design America in La Jolla, California, the first generation Murano was based on the Nissan FF-L platform first used by the third generation Altima. The European version of the Murano began sales in 2004 and is available only in one version.

The Murano was Nissan's only crossover SUV in the U.S. until September 2007 when the new 2008 Nissan Rogue went on sale. In Canada the X-Trail had been on sale as Nissan's second car-based SUV since 2004 as a 2005 model, it was replaced by the new 2008 Nissan Rogue in late 2007. The Murano is sized between the Xterra and the Pathfinder, but is priced slightly higher than the Nissan Pathfinder.

The Murano was nominated for the North American Truck of the Year award for 2003. It was also named the best premium mid-size SUV by AutoPacific.